Works

Cell competition

Live imaging of cell competition in Drosophila epithelial tissue

世界で初めて組織内細胞競合をライブで捉えた．神戸大医学部（当時）井垣研との共同研究．
Collaboration with Tatsushi Igaki lab.
NHK (Note: Movie was taken at RIKEN BSI, not RIKEN CDB.)


Mechanics of apical extrusion of transformed MDCK cells

ガン細胞排除の力学．京都大学藤田研との共同研究．
Collaboration with Yasu Fujita lab.


References

  • Shizue Ohsawa, Kaoru Sugimura, Kyoko Takino, Tian Xu, Atsushi Miyawaki, and Tatsushi Igaki.
    Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila.
    Developmental Cell 20: 315-328 (2011)　[PubMed] [The featured article of the issue]

  • Shizue Ohsawa, Kaoru Sugimura, Kyoko Takino, and Tatsushi Igaki.
    Imaging cell competition in Drosophila imaginal discs.
    Methods in Enzymology 506: 407-413 (2012)　[PubMed]

  • Mihoko Kajita, Kaoru Sugimura, Atsuko Ohoka, Jemima Burden, Hitomi Suganuma, Masaya Ikegawa, Takashi Shimada, Tetsuya Kitamura, Masanobu Shindoh, Susumu Ishikawa, Sayaka Yamamoto, Sayaka Saitoh, Yuta Yako, Ryosuke Takahashi, Takaharu Okajima, Junichi Kikuta, Yumiko Maijima, Masaru Ishii, Masazumi Tada, and Yasuyuki Fujita.
    Filamin acts as a key regulator in epithelial defence against transformed cells.
    Nature Communications 5: 4428 (2014)　[PubMed]

  • Keisuke Kuromiya, Kana Aoki, Kojiro Ishibashi, Moe Yotabun, Miho Sekai, Nobuyuki Tanimura, Sayuri Iijima, Susumu Ishikawa, Tomoko Kamasaki, Yuki Akieda,Tohru Ishitani, Takashi Hayashi, Satoshi Toda, Koji Yokoyama, Chol Gyu Lee, Ippei Usami, Haruki Inoue, Estelle Gauquelin, Kaoru Sugimura, Naoya Hino, Yasuyuki Fujita.
    Calcium sparks enhance the cellular fluidity within epithelial layers to promote apical extrusion of transformed cells.
    Cell Reports 40: 111078 (2022) [PubMed]

  • Estelle Gauquelin, Keisuke Kuromiya, Toshinori Namba, Keisuke Ikawa, Yasuyuki Fujita, Shuji Ishihara#, and Kaoru Sugimura#.
    Mechanical convergence in mixed populations of mammalian epithelial cells.
    European Physical Journal E 47: 21 (2024) [Journal] [bioRxiv]